Catalog Number: xAP-0647->Armenian Hamster Monoclonal anti-Mouse CD40 Antibody->CD40 is a 48 kD type I transmembrane glycoprotein, also known as Bp50. It is a member of the tumor necrosis factor receptor (TNFR) superfamily, expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+ hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with its ligand CD154 (gp39) expressed on activated T cells, is important in costimulation and immune regulation. The HM40-3 antibody has been reported to stimulate dendritic and B cell proliferation and block CD40-CD40L interactions. ->Size: 100ug->Immunogen: (BALB/c x NZB)F1 mouse-derived lymphoma WEHI 231 ->Clone: #HM40-3->Antibody Isotype: Armenian Hamster IgM->Species Reactivity: Armenian Hamster->Preparation: The antibody was purified by affinity chromatography. ->Formulation: The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS). ->Application : FC Block Costim IHC-F ->Storage & Handling: Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 0.5mg/ml. Reconstituted antibody can also be aliquoted and stored frozen at < -20C for at least for six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.