36-1957
Monoclonal Antibody to CD63 (Late Endosomes Marker)(Clone : NKI/C3)-PE
Abeomics
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DESCRIPTION
This MAb recognizes protein of 26kDa-60kDa, which is identified as CD63. Its epitope is different from that of MAb LAMP3/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
DETAILS
- Gene: CD63
- App Id: FACS,IF
- Antigen: CD63 (Late Endosomes Marker)
- Gene Id: 967
- Isotype: Mouse IgG1, kappa
- Format Id: Purified
- Clone Name: NKI/C3
- Uniprot Id: P08962
- Host Animal: Mouse
- Clonality Id: Monoclonal
- Conjugate Id: PE
- Purification: Affinity Chromatography
- Reactivity Id: Human, Mouse
- Product Content: PE conjugated CD63 Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.
- Alternative Name: CD63||MLA1||TSPAN30
- Application Note: Flow Cytometry (5ul per test per one million cells or 5ul per 100ul of whole blood);,Immunofluorescence (1:50-1:100 for 30 minutes at RT);,
- Storage Condition: Store the antibody at 4°C; stable for 6 months.
- Immunogen Information: Smooth plasma membrane fraction of MeWo cells