8819813-25mg 8819813-10mg
G-1
Biogems
DESCRIPTION
G-1 is a selective and potent agonist against the GPR30 receptor, an estradiol binding receptor that contributes to both uterine and neurological responses. G-1 inhibits the production of lipopolysaccharide (LPS) induced cytokines such as IL-6 and TNF-alpha. It is also reported to block MCF-1 cell cycle progression at the G1 phase and display therapeutic effects in multiple sclerosis models.
DETAILS
- Purity: ≥98%
- Synonyms: GPR30 Agonist, AC1MJFYZ, MLS001242405
- Cas Number: 881639-98-1
- References: Bologa, C. G., Revankar, C. M., Young, S. M., Edwards, B. S., Arterburn, J. B., Kiselyov, A. S., ... & Prossnitz, E. R. (2006). Virtual and biomolecular screening converge on a selective agonist for GPR30. Nature chemical biology,2(4), 207-212. Blasko, E., Haskell, C. A., Leung, S., Gualtieri, G., Halks-Miller, M., Mahmoudi, M., ... & Horuk, R. (2009). Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis. Journal of neuroimmunology, 214(1), 67-77. Kumar, R., Balhuizen, A., Amisten, S., Lundquist, I., & Salehi, A. (2011). Insulinotropic and antidiabetic effects of 17β-estradiol and the GPR30 agonist G-1 on human pancreatic islets. Endocrinology, 152(7), 2568-2579.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 1-[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]ethanone
- Molecular Weight: 412.3
- Molecular Formula: C21H18BrNO3
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CC(=O)C1=CC2=C(C=C1)NC(C3C2C=CC3)C4=CC5=C(C=C4Br)OCO5