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E0006Ca

Canine Interleukin 10, IL-10 ELISA Kit

Bioassay Technology Laboratory

DESCRIPTION

Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).

DETAILS

  • GeneID: 403628
  • Species: Canine
  • Storage: 2-8ºC
  • MASS(Da): 20,906
  • Synonyms: CSIF;Cytokine synthesis inhibitory factor;IL 10;IL10;IL-10;Interleukin-10
  • Assay Time: 1h 30m
  • Assay Type: Sandwich
  • Gene Names: IL10
  • Reactivity: Canine
  • Sample Type: Serum, plasma, cell culture supernates
  • Sensitivity: 1.02pg/ml
  • Target Protein: IL10
  • Detection Range: 2-700pg/ml
  • Full Product Name: Interleukin 10
  • Standard Solution: 800pg/ml
  • UniProt Accession: P48411