E0006Ca
Scientist.com Supplier
Canine Interleukin 10, IL-10 ELISA Kit
Bioassay Technology Laboratory
DESCRIPTION
Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
DETAILS
- Gene Id: 403628
- Uniprot: P48411
- Lead Time: 3 days
- Assay Type: Sandwich
- Sample Type: Serum, plasma, cell culture supernates
- Sensitivity: 1.02pg/ml
- Detection Range: 2-700pg/ml
- Detection Method: ELISA
- Species Reactivity: Canine