1293823-50mg 1293823-10mg 1293823-1mg
Y-27632 Dihydrochloride
Biogems
DESCRIPTION
Y-27632 is a selective inhibitor of Rho-associated coiled-coil forming protein serine/threonine kinase (ROCK) family of protein kinases that selectively competes with ATP for binding to the catalytic site. It is reported to diminish dissociation-induced apoptosis, increase cloning efficiency, and facilitate subcloning after gene transfer in human embryonic stem cells (hES).
DETAILS
- Purity: ≥98%
- Synonyms: Y 27632, N-(4-pyridyl)-4-(1-aminoethyl)cyclohexanecarboxamide, trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
- Cas Number: 129830-38-2
- References: Ishizaki, T., Uehata, M., Tamechika, I., Keel, J., Nonomura, K., Maekawa, M., & Narumiya, S. (2000). Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Molecular pharmacology, 57(5), 976-983. Fu, X., Gong, M. C., Jia, T., Somlyo, A. V., & Somlyo, A. P. (1998). The effects of the Rho-kinase inhibitor Y-27632 on arachidonic acid-, GTPγS-, and phorbol ester-induced Ca 2+-sensitization of smooth muscle. FEBS letters,440(1), 183-187. Watanabe, K., Ueno, M., Kamiya, D., Nishiyama, A., Matsumura, M., Wataya, T., ... & Sasai, Y. (2007). A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nature biotechnology, 25(6), 681-686.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide;dihydrochloride
- Molecular Weight: 320.3
- Molecular Formula: C14H21N3O2HCl
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CC(C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl