mouse monoclonal IgG1; Nrf2 Antibody (H-10) is an IgG1 κ mouse monoclonal Nrf2 antibody that detects Nrf2 of human origin by WB, IP, IF and ELISA. Nrf2 Antibody (H-10) is available as the non-conjugated anti-Nrf2 antibody form, as well as multiple conjugated forms of anti-Nrf2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The NF-E2 DNA binding protein is composed of two subunits, p45 and MafK. It regulates expression of globin genes in developing erythroid cells through interaction with Maf recognition elements (Mares). A family of NF-E2- related proteins, which are collectively known as the Cap 'n' collar (CNC) family and include Nrf1 (also designated TCF11), Nrf2 and Nrf3, are bZIP transcription factors that heterodimerize with Maf proteins to bind Mare sequences. The Nrf proteins also bind the antioxidant response element (ARE) and are implicated in the regulation of detoxification enzymes and the oxidative stress response. They do so by heterodimerizing with Jun family members (c-Jun, Jun B and Jun D) to activate gene expression, specifically the detoxifying enzyme NQO1. Nrf2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from its repressor protein, Keap1.