E6522Hu
Human Solute Carrier Family 12 Member 5, SLC12A5 ELISA Kit
Bioassay Technology Laboratory
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DESCRIPTION
Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl- homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl- levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity).
Involved in the regulation of dendritic spine formation and maturation (PubMed:24668262).
DETAILS
- GeneID: 57468
- Species: Human
- Storage: 2-8ºC
- MASS(Da): 126,184
- Synonyms: DEE34;EIEE34;EIG14;Electroneutral potassium-chloride cotransporter 2;hKCC2;KCC2;K-Cl cotransporter 2;Neuronal K-Cl cotransporter;SLC12A5;Solute carrier family 12 member 5
- Assay Time: 1h 30m
- Assay Type: Sandwich
- Gene Names: SLC12A5
- Reactivity: Human
- Sample Type: Serum, plasma, cell culture supernates
- Sensitivity: 6.97ng/L
- Target Protein: SLC12A5
- Detection Range: 15-3000ng/L
- Full Product Name: Solute carrier family 12 member 5
- Standard Solution: 3200ng/L
- UniProt Accession: Q9H2X9