Mut-7 Antibody (N-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 176347
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: mut-7
Other Names: Exonuclease mut-7, 31--, Exonuclease 3'-5' domain-containing protein 3 homolog, mut-7
Availability: 2 weeks
Bio Background: Mut-7 represses the transposition of Tc1, Tc3, Tc4, and Tc5, perhaps by degrading transposon-specific messages. This protein also affects sperm development, sensitivity to RNAi of mainly germline expressed genes, silencing of some germline transgenes, X chromosome loss, and is required for cosuppression (functional silencing of chromosomal loci induced by transgenes) and for silencing induced by antisense RNA oligomers.
Bio References: Topps, BB, et al. Nucleic Acids Res. 2005. 33(1):347-55.Ketting, R.F., et al. Cell 99:133-141(1999).Rizzon, C., et al. Genetics. 2003. 165(3):1127-35.
Primary Accession: P34607
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP1971a was selected from the N-term region of human Mut-7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.