HLA-B Antibody (Center) Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 3106
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: HLA-B
Other Names: HLA class I histocompatibility antigen, B-7 alpha chain, MHC class I antigen B*7, HLA-B, HLAB
Availability: 2 weeks
Bio Background: HLA-B belongs to the HLA class I heavy chain paralogues.This class I molecule is a heterodimer consisting of a heavy chainand a light chain (beta-2 microglobulin). The heavy chain isanchored in the membrane. Class I molecules play a central role inthe immune system by presenting peptides derived from theendoplasmic reticulum lumen. They are expressed in nearly allcells. The heavy chain is approximately 45 kDa and its genecontains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3encode the alpha1 and alpha2 domains, which both bind the peptide,exon 4 encodes the alpha3 domain, exon 5 encodes the transmembraneregion and exons 6 and 7 encode the cytoplasmic tail. Polymorphismswithin exon 2 and exon 3 are responsible for the peptide bindingspecificity of each class one molecule. Typing for thesepolymorphisms is routinely done for bone marrow and kidneytransplantation. Hundreds of HLA-B alleles have been described.
Bio References: Parsons, M.S., et al. J. Infect. Dis. 202 SUPPL 3, S356-S360 (2010) :Brockman, M.A., et al. J. Virol. 84(22):11937-11949(2010)Noble, J.A., et al. Diabetes 59(11):2972-2979(2010)Lipponen, K., et al. Diabetes (2010) In press :Liao, Y.Q., et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 18(4):1055-1058(2010)
Primary Accession: P01889