α-Zearalanol

DESCRIPTION

An active metabolite of α-zearalenol that acts as an ER agonist; inhibits [3H]estradiol binding to estrogen receptors on calf uterus in a dose-dependent manner; increases endometrial thickness, bone mineral density, and serum levels of alkaline phosphatase in ovariectomized rats at a dose of 10 mg/kg per day; decreases sperm count and motility and serum levels of testosterone, FSH, and LH in male mice

DETAILS

Inchi: InChI=1S/C18H26O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h10-12,14,19-21H,2-9H2,1H3/t12-,14+/m0/s1
Purity: ≥95%
Raptas: Product Type|Biochemicals|Lipids|Polyketides||Product Type|Biochemicals|Natural Products|Polyketides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Toxicology & Xenobiotic Metabolism|Drug Metabolites||Research Area|Toxicology & Xenobiotic Metabolism|Environmental Toxicology|Animal-Based Agriculture||Research Area|Toxicology & Xenobiotic Metabolism|Environmental Toxicology|Plant-Based Agriculture||Research Area|Toxicology & Xenobiotic Metabolism|Organ- & System-Specific Toxicity|Endocrine Disruption||Research Area|Toxicology & Xenobiotic Metabolism|Organ- & System-Specific Toxicity|Reproductive||Research Area|Toxicology & Xenobiotic Metabolism|Toxic Agents|Toxins
Smiles: OC1=C(C(O[C@@H](C)CCC[C@H](O)CCCCC2)=O)C2=CC(O)=C1
Inchikey: DWTTZBARDOXEAM-GXTWGEPZSA-N
Cas Number: 26538-44-3
Formulation: A solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C18H26O5
Formula Weight: 322.4
Shelf Life Days: 1460