Anti-CLASP1 Antibody [JE43-19]

DESCRIPTION

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.

DETAILS

Host: Rabbit
Type: Primary
Uniprot: SwissProt: Q7Z460 Human;SwissProt: Q80TV8 Mouse;Entrez Gene: 304740 Rat
Clone Id: JE43-19
Clonality: Recombinant Rabbit monoclonal Antibody
Conjugate: Non-conjugated
Alias Names: 1700030C23Rik antibody 5730583A19Rik antibody B130045P17Rik antibody CLAP1_HUMAN antibody clasp1 antibody CLIP associating protein 1 antibody CLIP associating protein CLASP1 antibody CLIP-associating protein 1 antibody Cytoplasmic linker associated protein 1 antibody Cytoplasmic linker-associated protein 1 antibody DKFZp686D1968 antibody DKFZp686H2039 antibody FLJ33821 antibody FLJ41222 antibody hOrbit1 antibody KIAA0622 antibody MAST1 antibody MGC131895 antibody mKIAA0622 antibody Multiple asters 1 antibody Multiple asters homolog 1 antibody Protein Orbit homolog 1 antibody
Application: WB,IF-Cell,IF-Tissue,IHC-P,FC
Epitope Region: Synthetic peptide within Human CLASP1 aa 1-50 / 1,538.
Protein Target: hOrbit1, CLASP1, KIAA0622, MAST1
Target Species: Human,Mouse,Rat
Species Reactivity: Human,Mouse,Rat