mouse monoclonal IgG1; Matriptase Antibody (D-7) is an IgG1 κ mouse monoclonal Matriptase antibody (also designated ST14 antibody, MT-SP1 antibody, Prostamin antibody, SNC19 antibody, TADG15 antibody or PRSS14 antibody) that detects the Matriptase protein of human origin by WB, IP, IF, IHC(P) and ELISA. Matriptase Antibody (D-7) is available as both the non-conjugated anti-Matriptase antibody form, as well as multiple conjugated forms of anti-Matriptase antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Matriptase (also known as MT-SP1, ST14, prostamin and epithin) is a tumor-associated type II transmembrane serine protease that is highly expressed in many human cancer-derived cell lines and is implicated in extracellular matrix re-modeling, tumor growth, and metastasis (1-7). Matriptase performs pleiotropic functions in the development of the epidermis, hair follicles, and cellular immune system. Sphingosine 1-phosphate (S1P, SPP), present in serum-derived lipoproteins, activates matriptase while matriptase activates both urokinase-type plasminogen activator and hepatocyte growth factor (HGF). Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is a Kunitz-type serine protease inhibitor identified as a strong inhibitor of matriptase and HGF. Advanced-stage ovarian tumors that express matriptase are more likely to do so in the absence of its inhibitor, HAI-1, indicating that an imbalance in the matriptase:HAI-1 ratio could be important in the development of advanced disease.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.