17372
Scientist.com Supplier
GSK2656157
Cayman Chemical
DESCRIPTION:
A selective inhibitor of PERK (IC50 = 0.9 nM); blocks both stress-induced PERK autophosphorylation and eIF2α substrate phosphorylation and decreases levels of ATF4 and CHOP in multiple cell lines
DETAILS
- Inchi: InChI=1S/C23H21FN6O/c1-13-4-3-5-14(28-13)10-19(31)30-9-8-16-18(30)7-6-15(21(16)24)17-11-29(2)23-20(17)22(25)26-12-27-23/h3-7,11-12H,8-10H2,1-2H3,(H2,25,26,27)
- Purity: ≥98%
- Raptas: Product Type|Biochemicals|Kinase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling
- Smiles: NC1=NC=NC2=C1C(C3=CC=C4C(CCN4C(CC5=CC=CC(C)=N5)=O)=C3F)=CN2C
- Inchikey: PRWSIEBRGXYXAJ-UHFFFAOYSA-N
- Cas Number: 1337532-29-2
- Formulation: A crystalline solid
- Storage Temp: -20
- Shipping Temp: -20
- Formula Markup: C23H21FN6O
- Formula Weight: 416.5
- Shelf Life Days: 1460