DESCRIPTION

• Notes: Troubleshooting Guide: Visit bpsbioscience.com/cell-line-faq for detailed troubleshooting instructions. For all further questions, please email support@bpsbioscience.com.
• Uniprot: Q16620
• Shiptemp: -80°C (dry ice)
• Synonyms: GP145-TrkB (Trk-B), Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin-related kinase B
• Warnings: Avoid freeze/thaw cycles. 
• Category: Kinase/Assay Kit
• Background: Tropomyosin receptor kinase B (TRKB) is a high-affinity catalytic receptor for neurotrophins and is part of a large family of tyrosine kinases. Once activated by specific neurotrophins, such as brain derived neurotrophic factor (BDNF), TRKB mediates neuronal differentiation and survival. TRKB and BDNF have been associated with the pathology and progression of Alzheimer's disease and other neurodegenerative disorders. More recently as a member of TRK proto-oncogene family, TRKB inhibitors have become of interest as a possible cancer therapy. 
• Description: The TRKB Kinase Assay Kit is designed to measure TRKB kinase activity for screening and profiling applications using ADP-Glo® as a detection reagent. 
• Methodology: Luminescent
• Supplied As: The TRKB Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant TRKB kinase, kinase substrate, ATP and kinase assay buffer for 100 enzyme reactions.
• Unspsc Code: 41105332
• Unspsc Name: Protein chemiluminescent detection reagents or kits or substrates
• Applications: Study enzyme kinetics and screen small molecular inhibitors for drug discovery and high throughput (HTS) applications.
• Product Type: Assay Kit
• Biosafety Level: Not applicable (BSL-1)
• Related Products: 79566, 79568, 79711, 79804
• Contraindications: The final concentration of DMSO in the assay should not exceed 1%. 
• Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed. 
• Scientific Category: Kinases