100-20B
Recombinant Human VEGF-B
PeproTech
DESCRIPTION
VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial cells, helps regulate angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. VEGF-B is expressed in all tissues except the liver. It forms cell surface-associated, disulfide-linked homodimers, and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B 167 and VEGF-B 186. Both forms have identical amino-terminal sequences encoding a cysteine knot-like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. Recombinant Human VEGF-B is a 38.0 kDa, disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.
DETAILS
- Gene Id: 7423
- Uniprot: P49765
- Activity: Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) in the presence of human VEGF 165. The expected ED50 for this effect is 1.0-2.0 ug/ml.
- Category: RUO Cytokines
- Subcategory: Growth Factors & Cytokines
- Research Areas: Angiogenesis/Cardiovascular, Cancer, Immune System, Inflammation, Neurobiology, Stem Cells and Differentiation
- Alternative Names: Vascular Endothelial Growth Factor-B, VEGF-related factor, VRF
- Species of Origin: Human
- Expression System Source: E.coli
Equivalent Items
| ... Loading