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18045

Azoramide

Cayman Chemical

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DETAILS

  • Inchi: InChI=1S/C15H17ClN2OS/c1-2-3-14(19)17-9-8-13-10-20-15(18-13)11-4-6-12(16)7-5-11/h4-7,10H,2-3,8-9H2,1H3,(H,17,19)
  • Purity: ≥98%
  • Raptas: Product Type|Biochemicals||Research Area|Cell Biology|Cellular Chaperones||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|ER Protein Folding||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes
  • Smiles: CCCC(NCCC1=CSC(C2=CC=C(Cl)C=C2)=N1)=O
  • Inchikey: VYBFWKKCWTXCQX-UHFFFAOYSA-N
  • Cas Number: 932986-18-0
  • Formulation: A crystalline solid
  • Storage Temp: -20
  • Shipping Temp: -20
  • Formula Markup: C15H17ClN2OS
  • Formula Weight: 308.8
  • Shelf Life Days: 1460

DESCRIPTION

A small molecule that at 1-25 µM improves ER protein-folding ability, stimulates the expression of multiple chaperone proteins, and induces phosphorylation of eIF2α to reduce protein synthesis; exerts antidiabetic activity in both ob/ob and diet-induced obese mice at 150 mg/kg, improving insulin sensitivity and glucose homeostasis, as well as protecting pancreatic β cells against ER stress