CC-92480

DESCRIPTION

A cereblon modulator; binds to cereblon (IC50 = 0.03 µM in a FRET assay) and induces the degradation of Ikaros and Aiolos in H929 R10-1 at 1, 10, and 100 nM; induces apoptosis in the same cells; reduces tumor growth in an H929 R10-1 mouse xenograft model at 1, 3, and 10 mg/kg

DETAILS

Inchi: InChI=1S/C32H30FN5O4/c33-26-16-23(17-34)8-9-27(26)37-14-12-36(13-15-37)18-21-4-6-22(7-5-21)20-42-29-3-1-2-24-25(29)19-38(32(24)41)28-10-11-30(39)35-31(28)40/h1-9,16,28H,10-15,18-20H2,(H,35,39,40)/t28-/m0/s1
Purity: ≥98%
Raptas: Product Type|Biochemicals||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Multidrug Resistance||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System
Smiles: FC1=CC(C#N)=CC=C1N2CCN(CC3=CC=C(COC4=C(CN([C@@]5([H])CCC(NC5=O)=O)C6=O)C6=CC=C4)C=C3)CC2
Inchikey: YTINZZFBHWSAGL-NDEPHWFRSA-N
Cas Number: 2259648-80-9
Formulation: A solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C32H30FN5O4
Formula Weight: 567.6
Shelf Life Days: 1460