T41148
Phototrexate
TargetMol
DESCRIPTION
Phototrexate is a photoswitchable potent inhibitor of human dihydrofolate reductase (DHFR). Phototrexate is a photochromic analog of Methotrexate. Antifolate activity is switched on (cis-Phototrexate) by UVA (375 nm) light; it can be switched off (trans-Phototrexate) by blue or white light and by thermal relaxation in the dark.cis-Phototrexate (IC50 = 6 nM) significantly reduces the viability of HeLa cells compared withtrans-Phototrexate (IC50 = 34 μM).
DETAILS
- Cas: 2268033-83-4
- Purity: 98%
- Smiles: NC=1C2=C(C=CC(/N=N/C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=C2)N=C(N)N1
- Category: Compound
- Molecular Weight: 437.41
- Molecular Formula: C20H19N7O5
Lead Time: Please Inquire
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