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T41148

Phototrexate

TargetMol

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DETAILS

  • Cas: 2268033-83-4
  • Purity: 98%
  • Smiles: NC=1C2=C(C=CC(/N=N/C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=C2)N=C(N)N1
  • Category: Compound
  • Molecular Weight: 437.41
  • Molecular Formula: C20H19N7O5

DESCRIPTION

Phototrexate is a photoswitchable potent inhibitor of human dihydrofolate reductase (DHFR). Phototrexate is a photochromic analog of Methotrexate. Antifolate activity is switched on (cis-Phototrexate) by UVA (375 nm) light; it can be switched off (trans-Phototrexate) by blue or white light and by thermal relaxation in the dark.cis-Phototrexate (IC50 = 6 nM) significantly reduces the viability of HeLa cells compared withtrans-Phototrexate (IC50 = 34 μM).

Lead Time: 4 - 5 weeks

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