Cilastatin

DESCRIPTION

An inhibitor of dipeptidase (dehydropeptidase I); inhibits human renal dipeptidase (Ki = 0.7 μM), porcine dipeptidase (IC50 = 0.11 μM), and bacterial metallo-β-lactamase CphA from A. hydrophila (IC50 = 178 μM); protects primary porcine renal proximal tubular epithelial cells from vancomycin-induced nephrotoxicity and apoptosis (200 μg/ml); protects mice from systemic infection by S. aureus, E. coli, and P. aeruginosa when administered in combination with imipenem; inhibits renal metabolism of imipenem to prolong its half-life

DETAILS

Inchi: InChI=1S/C16H26N2O5S/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23)/b12-6-/t10-,11+/m1/s1
Purity: ≥98%
Raptas: Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases
Smiles: OC([C@@H](N)CSCCCC/C=C(C(O)=O)\NC([C@@H]1C(C)(C)C1)=O)=O
Inchikey: DHSUYTOATWAVLW-WFVMDLQDSA-N
Cas Number: 82009-34-5
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C16H26N2O5S
Formula Weight: 358.5
Shelf Life Days: 1460