DESCRIPTION

• Form: Antigen Affinity Purified from Pooled Serum
• Gene: KCNB2
• Host: Rabbit
• Rrid: AB_2492211
• Type: Primary Antibody
• Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
• Target: Potassium Channel, Voltage Gated, Kv2.2 Subunit
• Isotype: IgG
• Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
• Shipping: Blue Ice
• Synonyms: delayed rectifier potassium channel protein antibody, KCNB2 antibody, KCNB2_HUMAN antibody, potassium channel Kv2.2 antibody, potassium voltage gated channel subfamily B member 2 antibody, Potassium voltage-gated channel subfamily B member 2 antibody, Voltage-gated potassium channel subunit Kv2.2 antibody
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from the subunit region of the voltage gated potassium channel from the rat and Xenopus Kv2.2 sequence, conjugated to keyhole limpet hemocyanin (KLH).
• Expiration: After date of receipt, stable for at least 1 year at -20°C.
• Specificity: Specific for endogenous levels of the ~125 kDa voltage gated potassium channel, Kv2.2 subunit.
• Applications: WB, IHC
• Ncbi Gene Id: 621349
• Conjugate Exem: Unconjugated
• Physical State: Liquid
• Usage Statement: For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
• Molecular Weight: 125
• Production Notes: Prepared from pooled rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.
• Dilution Range Wb: 1:1000
• Immunogen Species: Rat
• Dilution Range Ihc: 1:100-1:1000
• Species Reactivity: Rat and Xenopus
• Target Description: Voltage-gated K+ channels are important determinants of neuronal membrane excitability (Pongs, 1999). Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK)channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety of non-neuronal cells types including pancreatic islets, alveolar cells and cardiac myocytes (Hwang et al., 1993; Yan et al., 2004; Michaelevski et al., 2003). Kv2.1 and Kv2.2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells (Blaine and Ribera, 1998; Burger and Ribera, 1996).
• Uniprot Number Immunogen Species: Q63099

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