DESCRIPTION

• Shiptemp: -80°C (dry ice)
• Synonyms: Pim-2 proto-oncogene assay kit, serine/threonine kinase assay kit
• Warnings: Avoid multiple freeze/thaw cycles.
• Category: Kinase/Assay Kit
• Background: PIM kinases (PIM1, PIM2 and PIM3) are a family of serine/threonine protein kinases that play crucial roles in cell survival, proliferation, and drug resistance. PIM kinases are overexpressed in several tumors and promote growth and survival of malignant cells through cell cycle regulation and/or inhibition of apoptosis. Recently, PIM kinases were identified as a potential therapeutic target for precision medicine of advanced cancer.
• References: 1. Jeyapal G. P., et al., Anticancer Agents Med Chem, 2018, 18(8): 1100-11142. Asati V., et al., Eur J Med Chem. 2019, 172: 95-108
• Description: The PIM2 Assay Kit is designed to measure PIM2 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. 
• Methodology: Chemiluminescent
• Supplied As: The PIM2 Assay Kit comes in a convenient 96-well format, with enough purified recombinant PIM2 enzyme, PIM substrate (S6Ktide), ATP, and kinase assay buffer for 100 enzyme reactions.
• Unspsc Code: 41105332
• Unspsc Name: Protein chemiluminescent detection reagents or kits or substrates
• Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
• Product Type: Assay Kit
• Biosafety Level: Not applicable (BSL-1)
• Related Products: 41107, 41108, 79885, 79886
• Storage Stability: Up to 6 months when stored as recommended.
• Scientific Category: Kinase
• Instructions for Use: See assay protocol for detailed instructions.