BTL1038
β-Tubulin antibody
Biospes
DESCRIPTION
Tubulin is one of several members of a small family of globular proteins. The most common members of the tubulin family are α-tubulin and β-tubulin, the proteins that make up microtubules. Each has a molecular weight of approximately 55 kiloDaltons. Microtubules are assembled from dimers of α- and β-tubulin. These subunits are slightly acidic with an isoelectric point between 5.2 and 5.8. Mutant huntingtin, disrupted intracellular transport and insulin secretion by direct interference with microtubular beta-tubulin. Mutant huntingtin impaired glucose-stimulated insulin secretion in insulin-producing beta cells, without altering stored levels of insulin. Smith et al. (2009) proposed a novel pathogenetic process by which mutant huntingtin may disrupt hormone exocytosis from beta cells and possibly impair vesicular transport in any cell that expresses the pathogenic protein.
DETAILS
- Host: Mouse
- Isotype: IgG1
- Immunogen: Human β-Tubulin protein with full length.
- Lead Time: 1-2 weeks
- Alias Names: β-Tubulin, β-Tubulin antibody, β-Tubulin monoclonal antibody
- Applications: WB, IF, IHC
- Storage Buffer: In PBS (pH7.4), 50% Glycerol and 0.02% Sodium Azide.
- Species Reactivity: Human, mouse, rat
- Storage Instruction: Store at -20°C for 1 year. ; Avoid repeated freeze and thaw cycles.