5608212-10mg 5608212-1mg
Ionomycin Calcium Salt
Biogems
DESCRIPTION
Ionomycin is an ionphore discovered in Streptomyces conglobatus and used in the study of intracellular calcium. It is also reported to stimulate the intracellular production of IL-2, IL-4 and perforin. It is supplied as a a calcium salt for ease of storage.
DETAILS
- Purity: ≥98%
- Synonyms: IONOMYCINCALCIUMSALT
- Cas Number: 56092-82-1
- References: Liu, C. M., & Hermann, T. E. (1978). Characterization of ionomycin as a calcium ionophore. Journal of Biological Chemistry, 253(17), 5892-5894. Morgan, A. J., & Jacob, R. (1994). Ionomycin enhances Ca2+ influx by stimulating store-regulated cation entry and not by a direct action at the plasma membrane. Biochem. J, 300, 665-672. Elzi, D. J., Bjornsen, A. J., MacKenzie, T., Wyman, T. H., & Silliman, C. C. (2001). Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils. American Journal of Physiology-Cell Physiology, 281(1), C350-C360.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: calcium;(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-19,21-dihydroxy-22-[(2S,5S)-5-[(2R,5S)-5-[(1R)-1-hydroxyethyl]-5-methyloxolan-2-yl]-5-methyloxolan-2-yl]-4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxodocosa-10,16-dienoate
- Molecular Weight: 747.1
- Molecular Formula: C41H70O9 Ca
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CC(CCC(=O)[O-])CC(C)CC(C)C(=O)C=C(C(C)CC(C)CC=CC(C)C(C(C)C(CC1CCC(O1)(C)C2CCC(O2)(C)C(C)O)O)O)[O-].[Ca+2]