(+)-D-threo-PDMP (hydrochloride)

DESCRIPTION

A glucosylceramide synthase inhibitor; inhibits glucosylceramide synthase by 50% at a 5 µM in an enzyme assay; the active component of racemic DL-threo-PDMP; inhibits the synthesis of glucosylceramide synthase and lactosylceramide in B16 melanoma cells at 25 µM; inhibits B4GALT6 and prevents lactosylceramide synthesis; inhibits ganglioside biosynthesis, reduces long-term potentiation (LTP) in mouse hippocampal CA1 neurons, and impairs learning in the four-pellet taking test in mice

DETAILS

Inchi: InChI=1S/C23H38N2O3.ClH/c1-2-3-4-5-6-7-11-14-22(26)24-21(19-25-15-17-28-18-16-25)23(27)20-12-9-8-10-13-20;/h8-10,12-13,21,23,27H,2-7,11,14-19H2,1H3,(H,24,26);1H/t21-,23-;/m1./s1
Purity: ≥98%
Raptas: Product Type|Biochemicals|Small Molecule Inhibitors|Sphingolipid Turnover||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders|Multiple Sclerosis
Smiles: CCCCCCCCCC(N[C@@H]([C@H](O)C1=CC=CC=C1)CN2CCOCC2)=O.Cl
Inchikey: HVJHJOYQTSEKPK-BLDCTAJRSA-N
Cas Number: 139889-62-6
Formulation: A solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C23H38N2O3 • HCl
Formula Weight: 427
Shelf Life Days: 1460