17375
Empagliflozin
Cayman Chemical
DESCRIPTION
An SGLT2 inhibitor (IC50 = 3.1 nM for the human transporter); reduces non-fasting blood glucose levels, as well as aortic superoxide levels and cardiac interstitial fibrosis, in db/db mice when administered in the diet at 0.03%; decreases the severity of glomerulosclerosis, as well as reduces the escape latency in the Morris water maze, in the same model
DETAILS
- Inchi: InChI=1S/C23H27ClO7/c24-18-6-3-14(23-22(28)21(27)20(26)19(11-25)31-23)10-15(18)9-13-1-4-16(5-2-13)30-17-7-8-29-12-17/h1-6,10,17,19-23,25-28H,7-9,11-12H2/t17-,19+,20+,21-,22+,23-/m0/s1
- Purity: ≥98%
- Raptas: Product Type|Biochemicals|Antioxidants||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cardiovascular System|Heart||Research Area|Cardiovascular System|Kidney & Renal Disease|Diabetic Nephropathy||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen
- Smiles: ClC(C=CC([C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)=C2)=C2CC3=CC=C(O[C@@H]4COCC4)C=C3
- Inchikey: OBWASQILIWPZMG-QZMOQZSNSA-N
- Cas Number: 864070-44-0
- Formulation: A crystalline solid
- Storage Temp: -20
- Shipping Temp: -20
- Formula Markup: C23H27ClO7
- Formula Weight: 450.9
- Shelf Life Days: 1460