Biotinylated Human HLA-A*24:02&B2M&p53 (TYSPALNKMF) Complex Protein (Monomer, MALS verified)

DESCRIPTION

TP53 has been recognized as a tumor suppressor. 50% of cancers carry a TP53 mutation while many others affect other pathway components. High-copy numbers of WT p53 peptide-MHC class I complexes were detected on tumor cells as compared to low copies on normal cells. The Human HLA-A*0201 p53 (GLAPPQHLIRV) complex protein is a complex of HLA-A*0201 of the MHC Class I, B2M, and GLAPPQHLIRV peptide of the p53.

DETAILS

Tag: C-10×His & C-Avi
Host: HEK293
Size: 200ug
Buffer: PBS, pH7.4
Format: Powder
Purity: 95%
Source: Biotinylated Human HLA-A*24:02&B2M&p53 (TYSPALNKMF) Complex Protein (HLP-H82Eb) is expressed from human 293 cells (HEK293). It contains AA Gly 25 - Thr 305 (HLA-A*24:02) & Ile 21 - Met 119 (B2M) & TYSPALNKMF peptide (Accession # AAA59600.1 (HLA-A*24:02) & P61769 (B2M) TYSPALNKMF).
Storage: -20℃
Category: MABSol® Biotin Labeled Proteins
Molecule: HLA-A*2402 & B2M & p53 (TYSPALNKMF)
Conjugate: Biotin-labeled
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Gly 25 - Thr 305 (HLA-A*24:02) & Ile 21 - Met 119 (B2M) & TYSPALNKMF peptide
Swiss-prot: AAA59600.1 | P61769 | TYSPALNKMF
Package Size: 200ug*1
Characteristics: Biotinylated Human HLA-A*24:02&B2M&p53 (TYSPALNKMF) Complex Protein is produced by co-expression of HLA and B2M loaded with p53 peptide. This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 35.8 kDa and 11.7 kDa. The protein migrates as 39-42 kDa and 10 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 35.8 kDa and 11.7 kDa
Shipping Condition: RT
Species Reactivity: Human
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