• Purity: ≥98%
• Synonyms: 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide, Selisistat, EX527, SIRT1 Inhibitor III
• Cas Number: 49843-98-3
• References: Gertz, M., Fischer, F., Nguyen, G. T. T., Lakshminarasimhan, M., Schutkowski, M., Weyand, M., & Steegborn, C. (2013). Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism.Proceedings of the National Academy of Sciences, 110(30), E2772-E2781. Solomon, J. M., Pasupuleti, R., Xu, L., McDonagh, T., Curtis, R., DiStefano, P. S., & Huber, L. J. (2006). Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Molecular and cellular biology, 26(1), 28-38. Price, N. L., Gomes, A. P., Ling, A. J., Duarte, F. V., Martin-Montalvo, A., North, B. J., ... & Sinclair, D. A. (2012). SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell metabolism, 15(5), 675-690. Kabra, N., Li, Z., Chen, L., Li, B., Zhang, X., Wang, C., ... & Chen, J. (2009). SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. Journal of Biological Chemistry, 284(27), 18210-18217.
• Application: FA
• Formulation: Crystalline solid
• Chemical Name: 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
• Molecular Weight: 248.7
• Molecular Formula: C13H13ClN2O
• Storage Conditions: Product should be kept at -20°C.
• Pubchem Openeye Can Smiles: C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N

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