AF-450-10
Animal-Free Recombinant Human GDNF
PeproTech
DESCRIPTION
GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRalpha (alpha1-alpha4) receptors. GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. Using a Parkinson's disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional human GDNF ligand is a disulfide-linked homodimer consisting of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine-knot configuration. The calculated molecular weight of Recombinant Human GDNF is 30.4 kDa.
DETAILS
- Gene Id: 2668
- Uniprot: P39905
- Activity: Determined by a cell proliferation assay using SH-SY5Y cells. The expected ED50 for this effect is 1.0-10.0 ng/ml.
- Category: RUO Cytokines
- Subcategory: Animal-Free Cytokines
- Research Areas: Angiogenesis/Cardiovascular, Cell Culture, Immune System, Neurobiology, Stem Cells and Differentiation, TGF-beta Superfamily, Organoids
- Alternative Names: Glial-Derived Neurotrophic Factor, ATF-1
- Species of Origin: Human
- Expression System Source: E.coli
Equivalent Items
| ... Loading