KAT5 Blocking Peptide (C-Term)

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 10524
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: KAT5
Other Names: Histone acetyltransferase KAT5, 60 kDa Tat-interactive protein, Tip60, Histone acetyltransferase HTATIP, HIV-1 Tat interactive protein, Lysine acetyltransferase 5, cPLA(2)-interacting protein, KAT5, HTATIP, TIP60
Availability: 2 weeks
Bio Background: Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2.
Bio References: Kamine J.,et al.Virology 216:357-366(1996). Sheridan A.M.,et al.Mol. Cell. Biol. 21:4470-4481(2001). Legube G.,et al.Gene 310:161-168(2003). Ota T.,et al.Nat. Genet. 36:40-45(2004). Taylor T.D.,et al.Nature 440:497-500(2006).
Primary Accession: Q92993
Targetspecificity: The synthetic peptide sequence is selected from aa 387-398 of HUMAN KAT5