PGPC | Scientist.com

DESCRIPTION

Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes and activate PMNL.{8499} Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position.{9891} One of these substances An oxidized phospholipid found as a component in MM-LDL and in products of Ox-PAPC; activates PPARα in a concentration-dependent manner; increases VCAM1 and E-selectin expression in HAECs, as well as HAEC binding by monocytes and PMNs, in a concentration-dependent manner; increases total 5-lipoxygenase metabolites in murine RPMs at 37.5 μM; induces apoptosis in A7r5 rat aortic smooth muscle cells in vitro at 50 μM; levels are increased in the serum, LDL, and PBMCs of patients with coronary artery disease; UVA irradiation increases PGPC levels in cultured human skin fibroblasts

DETAILS

Inchi: InChI=1S/C29H56NO10P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-20-28(33)37-24-26(40-29(34)21-18-19-27(31)32)25-39-41(35,36)38-23-22-30(2,3)4/h26H,5-25H2,1-4H3,(H-,31,32,35,36)/t26-/m1/s1
Purity: ≥98%
Raptas: Product Type|Biochemicals|Lipids|Glycerophospholipids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Coronary Artery Disease||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Cardiovascular System|Vasculature|Smooth Muscle Cells||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Lipid Biochemistry|Glycerophospholipids||Research Area|Lipid Biochemistry|Reactive O2/N2 Pathways||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation
Smiles: CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCC[N](C)(C)C)OC(=O)CCCC(=O)O
Inchikey: CDZVJFRXJAUXPP-AREMUKBSSA-N
Cas Number: 89947-79-5
Formulation: A solution in ethanol
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C29H56NO10P
Formula Weight: 609.7
Shelf Life Days: 365