E4804Hu
Human Caspase 3, CASP3 ELISA Kit
Bioassay Technology Laboratory
DESCRIPTION
Involved in the activation cascade of caspases responsible for apoptosis execution (PubMed: 7596430). At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond (PubMed: 7774019). Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 (PubMed: 7596430). Involved in the cleavage of huntingtin (PubMed: 8696339). Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed: 21357690). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed: 23152800).
DETAILS
- GeneID: 836
- Species: Human
- Storage: 2-8ºC
- MASS(Da): 31,608
- Synonyms: Apopain;CASP 3;CASP3;CASP-3;Caspase-3;Caspase-3 subunit p12;Caspase-3 subunit p17;CPP-32;Cysteine protease CPP32;Protein Yama;SCA-1;SREBP cleavage activity 1
- Assay Time: 1h 30m
- Assay Type: Sandwich
- Gene Names: CASP3
- Reactivity: Human
- Sample Type: Serum, plasma, cell culture supernates
- Sensitivity: 0.027ng/ml
- Target Protein: CASP3
- Detection Range: 0.05-20ng/ml
- Full Product Name: Caspase 3
- Standard Solution: 24ng/ml
- UniProt Accession: P42574