1224999-10mg 1224999-1mg
StemRegenin 1 (SR1)
Biogems
DESCRIPTION
StemRegenin 1 (SR1) is a selective reversible antagonist of the aryl hydrocarbon receptor with a value of 50% inhibition concentration IC50 of 127 nM in CD34+ cells. It is reported to promote the self-renewal of human hematopoietic stem cells in culture by sustaining the cellular expression of CD34. StemRegenin 1 also stimulates the proliferation and differentiation of CD34+ hematopoietic progenitor cells into dendritic cells.
DETAILS
- Purity: ≥98%
- Synonyms: StemRegenin-1
- Cas Number: 1227633-49-9
- References: Thordardottir, S., Hangalapura, B. N., Hutten, T., Cossu, M., Spanholtz, J., Schaap, N., ... & Dolstra, H. (2013). The aryl hydrocarbon receptor antagonist StemRegenin 1 promotes human plasmacytoid and myeloid dendritic cell development from CD34+ hematopoietic progenitor cells. Stem cells and development, 23(9), 955-967. Boitano, A. E., Wang, J., Romeo, R., Bouchez, L. C., Parker, A. E., Sutton, S. E., ... & Schultz, P. G. (2010). Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science,329(5997), 1345-1348. Gori, J. L., Chandrasekaran, D., Kowalski, J. P., Adair, J. E., Beard, B. C., D'Souza, S. L., & Kiem, H. P. (2012). Efficient generation, purification, and expansion of CD34+ hematopoietic progenitor cells from nonhuman primate–induced pluripotent stem cells. Blood, 120(13), e35-e44
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 4-[2-[[2-(1-benzothiophen-3-yl)-9-propan-2-ylpurin-6-yl]amino]ethyl]phenol
- Molecular Weight: 429.5
- Molecular Formula: C24H23N5OS
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CC(C)N1C=NC2=C(N=C(N=C21)C3=CSC4=CC=CC=C43)NCCC5=CC=C(C=C5)O