2191178-25mg 2191178-10mg
PD 173074
Biogems
DESCRIPTION
PD 173074 is a potent and selective inhibitor of fibroblast growth factors, FGFR1 and FGFR3. It is reported to suppress the differentiation of mouse embryonic cells and promote the survival of human embryonic cells. PD 173074 potently and selectively antagonizes the neurotrophic and neurotropic actions of FGF-2 and displays anti-cancer properties.
DETAILS
- Purity: ≥98%
- Synonyms: PD173074, UNII-A4TLL8634Y, FGF/VEGF Receptor Tyrosine Kinase Inhibitor
- Cas Number: 219580-11-7
- References: Skaper, S. D., Kee, W. J., Facci, L., Macdonald, G., Doherty, P., & Walsh, F. S. (2000). The FGFR1 Inhibitor PD 173074 Selectively and Potently Antagonizes FGF‐2 Neurotrophic and Neurotropic Effects. Journal of neurochemistry, 75(4), 1520-1527. Mohammadi, M., Froum, S., Hamby, J. M., Schroeder, M. C., Panek, R. L., Lu, G. H., ... & Hubbard, S. R. (1998). Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. The EMBO journal, 17(20), 5896-5904. Dimitroff, C. J., Klohs, W., Sharma, A., Pera, P., Driscoll, D., Veith, J., ... & Bernacki, R. J. (1999). Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: implications for combination treatment with photodynamic therapy. Investigational new drugs, 17(2), 121-135.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea
- Molecular Weight: 523.7
- Molecular Formula: C28H41N7O3
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C