mouse monoclonal IgG2b; CCM3 Antibody (C-8) is an IgG2b κ mouse monoclonal CCM3 antibody (also designated CCM3 antibody) that detects the CCM3 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. CCM3 Antibody (C-8) is available as both the non-conjugated anti-CCM3 antibody form, as well as multiple conjugated forms of anti-CCM3 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Programmed cell death (apoptosis) of nonessential cells is necessary for embryogenesis, metamorphosis, tissue turnover and proper development and function of the immune system. CCM3, also known as Pdcd-10, is a member of the family of programmed cell death proteins that regulate apoptotic pathways. CCM3 is and anti-apoptotic protein that is essential for proper vascular development and maturation. Through direct interaction with and positive regulation of MST4 in the ERK pathway, CCM3 promotes proper cell growth and differentiation. Defects in the gene encoding CCM3 may be related to cerebral cavernous malformations 3 (CCM3), a disease characterized by vascular anomalies found in the central nervous system that can cause stroke, seizures and focal hemorrhages.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.