mouse monoclonal IgG2b; HBO1 Antibody (G-2) is an IgG2b κ mouse monoclonal HBO1 antibody (also designated HBO1 antibody) that detects the HBO1 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. HBO1 Antibody (G-2) is available as both the non-conjugated anti-HBO1 antibody form, as well as multiple conjugated forms of anti-HBO1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. In the cell, transcription is regulated in part by the histone modification of chromatin. Specifically, histone acetyltransferase proteins and their associated complexes function with co-activators to regulate transcription. One family of histone acetyltransferases is the MYST family of transcriptional silencers, which is linked to ORC (origin recognition complex) function. The ORC is an initiator protein for DNA replication and mediates the acetylation of chromatin to control both DNA replication and gene expression. HBO1 (histone acetyltransferase binding to ORC) is a MYST family protein that interacts with ORC1, the largest subunit of the human ORC complex. HBO1 is a nuclear protein that is highly expressed in human testis. In addition to binding ORC, HBO1 represses AR (androgen receptor)-mediated transcription by binding AR through its N-terminal transcriptional repression domain. HBO1 may play a role in regulating AR-dependent gene transcription in normal and prostate cancer cells.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.