Z03134-50
Scientist.com Supplier
IL-6, Human(CHO-expressed)
GenScript
DESCRIPTION
Interleukin-6 (IL-6), also known as BSF-2, CDF and IFNB2, is a pleiotropic cytokine that acts in both pro-inflammatory and anti-inflammatory responses. It is produced mainly by T cells, macrophages, monocytes, endothelial cells and muscle cells. IL-6 binds to IL-6 receptor (IL-6R) to trigger the association of IL-6R with gp130, inducing signal transduction through JAKs and STATs. The biological functions of IL-6 are diverse. It stimulates B cell differentiation and antibody production, myeloma and plasmacytoma growth, as well as nerve cell differentiation. It also acts as a myokine, produced by muscle cells in response to muscle contraction, to be released to the blood stream to help break down fats and improve insulin resistance.
DETAILS
- Form: Lyophilized
- Purity: > 95% as analyzed by SDS-PAGE
- Species: Human
- Product Line: Cytokines
- Expression System: CHO
- Storage Stability: Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles.
- Biological Activity: ED50 < 1.0 ng/ml, measured in a cell proliferation assay using TF-1 cells.
- Protein Construction: IL-6 (Pro29-Met212)\nAccession # Q75MH2