30-2293
Anti-CD180 Monoclonal Antibody (Clone:G28-8)-PE Conjugated
Abeomics
DESCRIPTION
CD180, also known as RP105 (or Bgp95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. Its cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression is dependent on the coexpression of its helper molecule, MD-1 , and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size.
DETAILS
- Gene: CD180
- App Id: FACS, IP, Functional Assay
- Antigen: CD180
- Gene Id: 4064
- Isotype: Mouse IgG1
- Clone Name: G28-8
- Uniprot Id: Q99467
- Host Animal: Mouse
- Clonality Id: Monoclonal
- Conjugate Id: PE
- Reactivity Id: Human
- Alternative Name: CD180||LY64||RP105
- Storage Condition: Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
- Immunogen Information: Human tonsillar B cells
Equivalent Items
| ... Loading