13121
Sodium Butyrate
Cayman Chemical
DESCRIPTION
A short-chain fatty acid; produced predominately by bacterial fermentation of dietary fiber in the colon but has also been identified in mammalian milk; an HDAC inhibitor (IC50 = 90 µM in a cell-free assay); induces differentiation, cell cycle arrest at the G0 phase, and apoptosis, as well as inhibits proliferation, in a variety of cancer cells from 0.6-100 mM; decreases the expression of IFN-γ-related signaling genes and metastatic genes in H460 human lung cancer cells at 2 mM; reduces tumor growth in a CaSki mouse xenograft model at 200 and 800 mg/kg per day; reduces increases in colonic TNFa and Il6 expression and decreases colonic goblet cell depletion, tissue damage, muscle thickening, and cellular infiltration in a wild-type, but not Hcar2-/-, mouse model of TNBS-induced colitis
DETAILS
- Inchi: InChI=1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
- Purity: ≥95%
- Raptas: Product Type|Biochemicals|Lipids|Fatty Acids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|RARs, RORs, & RXRs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation||Research Area|Immunology & Inflammation|Gastric Disease|Ulcerative Colitis||Research Area|Lipid Biochemistry|Fatty Acids
- Smiles: CCCC([O-])=O.[Na+]
- Inchikey: MFBOGIVSZKQAPD-UHFFFAOYSA-M
- Cas Number: 156-54-7
- Formulation: A crystalline solid
- Item Origin: Synthetic
- Storage Temp: 22
- Shipping Temp: 22
- Formula Markup: C4H7O2 • Na
- Formula Weight: 110.1
- Shelf Life Days: 1460