PSMB5 Antibody (C-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 5693
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: PSMB5
Other Names: Proteasome subunit beta type-5, Macropain epsilon chain, Multicatalytic endopeptidase complex epsilon chain, Proteasome chain 6, Proteasome epsilon chain, Proteasome subunit MB1, Proteasome subunit X, PSMB5, LMPX, MB1, X
Availability: 2 weeks
Bio Background: The proteasome is a multicatalytic proteinase complex witha highly ordered ring-shaped 20S core structure. The core structureis composed of 4 rings of 28 non-identical subunits; 2 rings arecomposed of 7 alpha subunits and 2 rings are composed of 7 betasubunits. Proteasomes are distributed throughout eukaryotic cellsat a high concentration and cleave peptides in anATP/ubiquitin-dependent process in a non-lysosomal pathway. Anessential function of a modified proteasome, the immunoproteasome,is the processing of class I MHC peptides. This gene encodes amember of the proteasome B-type family, also known as the T1Bfamily, that is a 20S core beta subunit in the proteasome. Thiscatalytic subunit is not present in the immunoproteasome and isreplaced by catalytic subunit 3i (proteasome beta 8 subunit).Multiple transcript variants encoding different isoforms have beenfound for this gene.
Bio References: Ri, M., et al. Leukemia 24(8):1506-1512(2010)Lu, S., et al. Exp. Hematol. 37(7):831-837(2009)Lu, S., et al. Exp. Hematol. 36(10):1278-1284(2008)Oerlemans, R., et al. Blood 112(6):2489-2499(2008)Wang, L., et al. Clin. Cancer Res. 14(11):3503-3513(2008)
Primary Accession: P28074