Ganglioside GM1 (ovine) (ammonium salt)

DESCRIPTION

A mixture of ganglioside GM1 species isolated from ovine brain with primarily C18:0 fatty acyl chain lengths, among various others; enriched in lipid rafts; associates with growth factor receptors and is required for TrkA expression on the cell surface; interacts with other proteins to increase calcium influx, affecting various calcium-dependent processes, including inducing neuronal outgrowth during differentiation; acts as a receptor for cholera toxin and the heat-labile enterotoxin from E. coli; accumulates in neurons in ganglioside GM1 gangliosidosis; levels are decreased in the substantia nigra pars compacta in postmortem brain from patients with Parkinson’s disease

DETAILS

Inchi: InChI=1S/C73H131N3O31.H3N/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-52(87)76-44(45(84)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)41-98-69-61(94)59(92)63(50(39-80)101-69)103-71-62(95)67(107-73(72(96)97)35-46(85)53(74-42(3)82)66(106-73)55(88)47(86)36-77)64(51(40-81)102-71)104-68-54(75-43(4)83)65(57(90)49(38-79)99-68)105-70-60(93)58(91)56(89)48(37-78)100-70;/h31,33,44-51,53-71,77-81,84-86,88-95H,5-30,32,34-41H2,1-4H3,(H,74,82)(H,75,83)(H,76,87)(H,96,97);1H3/b33-31+;/t44-,45+,46-,47+,48+,49+,50+,51+,53+,54+,55+,56-,57-,58-,59+,60+,61+,62+,63+,64-,65+,66+,67+,68-,69+,70-,71-,73-;/m0./s1
Purity: ≥98%
Raptas: Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Immunology||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Infectious Disease|Bacterial Diseases|Cholera||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease
Smiles: [H][C@](CO[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O[C@@H]3O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)O)O)CO)O[C@@]5(C([O-])=O)O[C@]([C@@H]([C@@H](CO)O)O)([H])[C@H](NC(C)=O)[C@@H](O)C5)O)CO)([C@@H](/C=C/CCCCCCCCCCCCC)O)NC([R])=O.[NH4+]
Inchikey: XKTKEUMFELHBSG-POYTVKKJSA-N
Cas Number: 1007119-81-4
Formulation: A solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C73H130N3O31 • NH4 (for stearoyl)
Formula Weight: 1563.9
Shelf Life Days: 1460