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Animal-Free Recombinant Human IL-36gamma (IL-1F9)



The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36 alpha (IL-1F6), beta (IL-1F8) and gamma (IL-1F9). IL-36gamma is highly expressed in psoriatic plaques and in tissues containing epithelial cells. IL-36gamma signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36gamma also functions as an agonist of NF-kappaB, and can stimulate the inflammatory response in bronchial epithelial cells. Recombinant Human IL-36gamma is a 17.0 kDa protein containing 152 amino acid residues.


  • Gene Id: 56300
  • Uniprot: Q9NZH8
  • Activity: Measured by its ability to induce IL-8 production by human PBMCs.
  • Category: RUO Cytokines
  • Subcategory: Animal-Free Cytokines
  • Research Areas: Cancer, Diabetes/Weight Regulation, Immune System, Inflammation, Neurobiology, Wound Healing
  • Alternative Names: Interleukin-36gamma, IL-1F, IL-1ε (epsilon), IL-1H1
  • Species of Origin: Human
  • Expression System Source: E.coli