12-9040
Anti-CTLA-4 antibody(DM50), Rabbit mAb
Abeomics
DESCRIPTION
Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.
DETAILS
- App Id: ELISA,FACS
- Isotype: Rabbit IgG
- Clone Name: DM50
- Host Animal: Rabbit
- Clonality Id: Monoclonal
- Purification: Purified from cell culture supernatant by affinity chromatography
- Reactivity Id: Human
- Product Content: Preservative: 0.1% Procline 300 Constituents: 50% Glycerol; PBS,pH 7.4; 0.1% BSA
- Alternative Name: CTLA4, CD152
- Application Note: Recommended Dilutions ELISA 1/5000-10000;FACS 1/100
- Storage Condition: Store at -20°C for 12 months (Avoid repeated freezing and thawing)
- Shipping Condition: Delivery in 1-2 weeks
- Immunogen Information: Recombinant human CTLA4(Gln36-Ser161) produced by using human HEK293 cells