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E2011Hu

Human Beclin-1, BECN1 ELISA Kit

Bioassay Technology Laboratory

DESCRIPTION

Plays a central role in autophagy (PubMed: 23184933, PubMed: 28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed: 20643123, PubMed: 20208530, PubMed: 26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed: 25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed: 9765397). May play a role in antiviral host defense. Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.

DETAILS

  • GeneID: 8678
  • Species: Human
  • Storage: 2-8ºC
  • MASS(Da): 51,896
  • Synonyms: Beclin-1;Beclin-1-C 35 kDa;Beclin-1-C 37 kDa;BECN 1;BECN1;Coiled-coil myosin-like BCL2-interacting protein;Protein GT197
  • Assay Time: 1h 30m
  • Assay Type: Sandwich
  • Gene Names: BECN1
  • Reactivity: Human
  • Sample Type: Serum, plasma, cell culture supernates
  • Sensitivity: 0.1ng/ml
  • Target Protein: BECN1
  • Detection Range: 0.2-60ng/ml
  • Full Product Name: Beclin-1
  • Standard Solution: 64ng/ml
  • UniProt Accession: Q14457