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7142861-10mg 7142861-1mg

TTNPB

Biogems

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DETAILS

  • Purity: ≥98%
  • Synonyms: AGN-191183, Arotinoid acid, Arotinoic acid, Ro 13-7410
  • Cas Number: 71441-28-6
  • References: Pignatello, M. A., Kauffman, F. C., & Levin, A. A. (1997). Multiple factors contribute to the toxicity of the aromatic retinoid, TTNPB (Ro 13-7410): binding affinities and disposition. Toxicology and applied pharmacology, 142(2), 319-327. Åström, A., Pettersson, U., Krust, A., Chambon, P., & Voorhees, J. J. (1990). Retinoic acid and synthetic analogs differentially activate retinoic acid receptor dependent transcription. Biochemical and biophysical research communications, 173(1), 339-345. Hossain, M. Z., & Bertram, J. S. (1994). Retinoids suppress proliferation, induce cell spreading, and up-regulate connexin43 expression only in postconfluent 10T1/2 cells: implications for the role of gap junctional communication. Cell growth & differentiation: the molecular biology journal of the American Association for Cancer Research, 5(11), 1253-1261.
  • Application: FA
  • Formulation: Crystalline solid
  • Chemical Name: 4-[(E)-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)prop-1-enyl]benzoic acid
  • Molecular Weight: 348.5
  • Molecular Formula: C24H28O2
  • Storage Conditions: Product should be kept at -20°C.
  • Pubchem Openeye Can Smiles: CC(=CC1=CC=C(C=C1)C(=O)O)C2=CC3=C(C=C2)C(CCC3(C)C)(C)C

DESCRIPTION

TTNPB is a retinoic acid analog that selectively and potently activates the retinoic acid receptors. It is reported to increase the efficiency of induced pluripotent stem cell (iPSC) chemical reprogramming.