T14304
Aphidicolin
TargetMol
DETAILS
- Cas: 38966-21-1
- Purity: 98%
- Smiles: C[C@@]12[C@]34[C@](C[C@](C3)([C@](CO)(O)CC4)[H])(CC[C@]1([C@@](CO)(C)[C@H](O)CC2)[H])[H]
- Category: Compound
- Molecular Weight: 338.48
- Molecular Formula: C20H34O4
DESCRIPTION
Aphidicolin, an antibiotic derived from the mold Cephalosporium aphidicola, is a potent inhibitor of DNA (deoxyribonucleic acid) synthesis, effectively hindering the proliferation of herpes simplex virus[2]. It targets DNA polymerase α and δ, disrupting mitotic cell division by affecting DNA polymerase activity[1]. Additionally, aphidicolin enhances apoptosis when combined with arabinosyl nucleosides in a human promyelocytic leukemia cell line[3].
Lead Time: 4 - 5 weeks
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