mouse monoclonal IgG2b; Peroxin 13 Antibody (D-5) is an IgG2b κ mouse monoclonal Peroxin 13 antibody (also designated PEX13 antibody) that detects the Peroxin 13 protein of mouse, rat and human origin by WB, IP, IF and ELISA. Peroxin 13 Antibody (D-5) is available as both the non-conjugated anti-Peroxin 13 antibody form, as well as multiple conjugated forms of anti-Peroxin 13 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Peroxisomes are single-membrane bounds organelles present in virtually all eukaryotic cells. They are involved in numerous catabolic and anabolic pathways, including beta-oxidation of very long chain fatty acids, metabolism of hydrogen peroxide, plasmalogen biosynthesis, and bile acid synthesis. The Peroxin gene family, which includes more than 20 members, is required for peroxisome biogenesis. Two members of this family, Peroxin 5 (Pex5) and Peroxin 7 (Pex7), are receptors for proteins that contain the peroxisome targeting signal 1 (PTS1) and 2 (PTS2), respectively, and shuttle these proteins from the cytosol to the peroxisome. Peroxin 5, also designated PTS1 receptor, is expressed as two isoforms, Pex5L and Pex5S. Pex5L transports PTS1 and Pex7-PTS2 cargo complexes to the initial Pex5 docking site, Pex14, while Pex5S transports only PTS1 cargoes. Pex5 and Pex7 also require either direct or indirect interaction with Peroxin 13 (Pex13) for proper import into peroxisomes. Pex13 encodes an SH3-containing peroxisomal membrane protein that binds to sequences lacking a PXXP motif, which includes Pex5. Pex13 has high expression in liver and testis. Pex13 dysfunction is also implicated in some peroxisome biogenesis disorders.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.