T36468
ARN14988
TargetMol
DESCRIPTION
ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme). It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide and C16 ceramide in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 μM, respectively).
DETAILS
- Cas: 1502027-70-4
- Purity: 98%
- Smiles: C(OCC(C)C)(=O)N1C(=O)N(C(NCCCCCC)=O)C=C(Cl)C1=O
- Category: Compound
- Molecular Weight: 373.83
- Molecular Formula: C16H24ClN3O5
Lead Time: Please Inquire
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