DESCRIPTION

• Aa: 20-336
• Mw: 37 kDa + glycans
• Tags: C-terminal Avi-Tag™, His-Tag
• Format: Aqueous buffer solution.
• Purity: ≥90%
• Genbank: NM_000591
• Species: Human
• Uniprot: P08571
• Shiptemp: -80°C (dry ice)
• Synonyms: Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein
• Warnings: Avoid freeze/thaw cycles
• Category: Immunotherapy/Protein
• Background: CD14 (Cluster of Differentiation-14) is a surface antigen expressed predominantly by monocytes and macrophages. It is considered a patterned recognition receptor (PRR), which recognizes pathogen markers. Specifically, CD14 acts as a co-receptor for lipopolysaccharides (LPS) found in the outer membrane of gram-negative bacteria. Through this interaction, CD14 supports initiation of the innate immune response during bacterial infection. CD14 also contributes toward immune responses to viral pathogens such as human respiratory syncytial virus (RSV) and may amplify the inflammatory response observed in severe cases of SARS-CoV-2 infection (COVID-19). Monoclonal antibodies against CD14 are currently undergoing clinical trial as a candidate treatment to limit severe inflammatory responses common in patients hospitalized with COVID-19.
• Description: Recombinant human CD14 molecule, encompassing amino acids 20-336. This construct contains a C-terminal Avi-Tag™ followed by a His-tag (6xHis). The protein was affinity purified. 
• Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
• Unspsc Code: 12352202
• Unspsc Name: Proteins
• Host Species: Human
• Product Type: Protein
• Host Cell Line: HEK293
• Biosafety Level: Not applicable (BSL-1)
• Related Products: 101187, 78335, 101883, 101884
• Storage Stability: At least 6 months at -80°C.
• Scientific Category: Immunotherapy
• Instructions for Use: Thaw on ice and gently mix prior to use. DO NOT VORTEX. Perform a quick spin before opening. Aliquot into small volumes and flash freeze for long term storage. Avoid multiple freeze/thaw cycles.