T69646
JS25
TargetMol
DESCRIPTION
JS25 is a selective, covalent BTK inhibitor that deactivates BTK by chelating Tyr551, exhibiting an IC50 of 5.8 nM. It suppresses cancer cell proliferation, induces pronounced cell death, and enhances Burkitt's lymphoma murine xenograft model outcomes. Importantly, JS25 efficiently penetrates the blood-brain barrier.
DETAILS
- Cas: 2411771-95-2
- Purity: 98%
- Smiles: O=C1N(C2=C3C(C=C(C=C3)C4=CC=C(NS(C)(=O)=O)C=C4)=NC=C2C=C1)C5=CC(NC(C=C)=O)=CC(C)=C5
- Category: Compound
- Molecular Weight: 524.59
- Molecular Formula: C29H24N4O4S
Lead Time: 4 - 5 weeks
Sign in to view pricing