mouse monoclonal IgG1; GDF-15 Antibody (G-5) is an IgG1 κ mouse monoclonal GDF-15 antibody (also designated GDF15 antibody, or MIC1 antibody) that detects the GDF-15 protein of human origin by WB, IP, IF, IHC(P) and ELISA. GDF-15 Antibody (G-5) is available as both the non-conjugated anti-GDF-15 antibody form, as well as multiple conjugated forms of anti-GDF-15 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Growth differentiation factor 15 (GDF-15), also known as PDF, MIC-1, PLAB, NAG-1 or PTGF-β, is a member of the transforming growth factor beta (TGF-beta) superfamily. Synthesized intracellularly, the protein is secreted as a dimer linked by disulfide bonds. Epithelial cells and macrophages are the sites of strongest GDF-15 expression, although it is widely expressed in adult tissue. In the brain, GDF-15 expression occurs in the choroid plexus, from which the protein is secreted into the cerebrospinal fluid. The gene for GDF-15 is responsive to p53 tumor suppressor protein, and in cultured cerebellar granule neurons GDF-15 can prevent cell death by the activation of Akt and inhibition of ERK. GDF-15 acts as a trophic factor for certain classes of neurons, promoting cell survival and differentiation. Overexpression of GDF-15 occurs in prostate cancer, and may be a means of diagnosis. In the uterus, GDF-15 may work to suppress maternally derived proinflammatory cytokines, thereby promoting fetal survival.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.